Comt Gene

COMT is an enzyme involved in catecholamine neurotransmitter metabolism. A known gene produces this enzyme and it is polymorphic. passel have one of triplet genotypes. The effect of the gene on bad psychosis depends on the degree of hangmans rope usage in adolescence. The outset article discusses the run a risk for psychosis in maturity date among teenaged marijuana users. The hypothesis stated that carriers of the Val allele would be at greatest risk for the potential long-term psychotogenic do of hemp (Caspi, et.al). In this article, the researchers too discussed the hypothesis that a usable pleomorphism of the COMT gene may moderate the association in the midst of cannabis use and the risk of develop psychosis (Caspi, et. al). A cohort pillowcase field is a form of longitudinal test that involves analysis of risk factors and follows a group of mess who do not have a particular disease, and uses correlations to look the absolute risk of subject contractio n. This design involved 1,037 children of which 52% were male. The birth cohort was launch at the age of three when 91% of consecutive births between March 1972 and March 1973 in Dunedin, New England were enrolled by the researchers. The families of the children represent a wide florilegium of socioeconomic backgrounds.

Follow-ups were conducted at the ages of 3, 5,7,9,11,13,15,18,21, and 26. deoxyribonucleic acid was obtained from 953 participants when they reached the age of 26. DNA samples were obtained each through blood or through buccal swabs. The SNipTag technique was used by the researchers to beatnik the activity of the COMT functional single nucleotide polymorphism V! al. A psychiatric interview was also conducted at age 26 to assess the presence of psychosis. The results of this study confirm the hypothesis that a functional polymorphism in the Catechol-O-Methyltransferase (COMT) gene moderates the effect of cannabis use during adolescence on developing psychosis during adulthood. The second article discusses the routine of...If you want to get a full essay, order it on our website: BestEssayCheap.com

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